Abstract

ABSTRACT:
BACKGROUND:
Dyslipidemia is common in Patients with chronic renal failure undergoing intermittent haemodialysis and is considered a risk factor of cardiovascular disease in these patients.
OBJECTIVE:
To highlight the lipid profile abnormalities in children with end stage renal disease undergoing maintenance hemodialysis and know whether the hemodialysis duration and frequency of sessions per week has any impact on lipid profile in these patients.
PATIENTS AND METHOD:
A case-control study which was collected in the dialysis unit of (Al Karama Teaching Hospital, Child's Central Teaching Hospital , Al Kadhumia Teaching Hospital and Ibn Al Balady Hospital) for six months started on 1st June 2013 till the 1st of December 2013. Blood samples were obtained from 40 patients with end stage renal disease undergoing maintenance haemodialysis (2-3 sessions per week) and 40 matched healthy controls and analyzed for serum total cholesterol, low density lipoproteins, high density lipoprotein and serum triglyceride.
RESULTS:
A statistically significant decrease was found in serum high density lipoprotein level (Mean= 46.40mg/dl ,p < 0.025) in Hemodialysis patients when compared with healthy controls. A significant increase in serum triglyceride content of patients (p < 0.000) was also observed. It was found that improvements in lipid profile results were achieved with the use of more frequent (more than 2sessions of haemodialysis per week). There is no any impact of the duration being on HD on the lipid profile in the study.
CONCLUSION:
This study found that normal lipid profile is better maintained in patients undergoing adequate haemodialysis, and the frequency of haemodialysis sessions can affect the atherogenic states of the lipid profile which is probably the responsible for high incidence of atherosclerotic heart diseases among these patients.