Abstract
BACKGROUND:
Nausea and vomiting are the commonest complication Post-operatively which are usually self-limiting; however, it can cause serious consequences. There are many drugs to manage Post-operative nausea and vomiting.
OBJECTIVE:
Compare the efficacy of transdermal scopolamine versus ondansetron for the prevention of post-operative laparoscopic cholecystectomy emetic symptoms.
PATIENTS AND METHODS:
One hundred patients who were candidate for undergoing laparoscopic cholecystectomy are divided in to two groups each of them have 50 patients, first group received an active TDS patch (containing scopolamine 1.5 mg) 60 min before entering the operating room. The second group was administered ondansetron, 4 mg that was administered I.V near the end of the procedure, and all patients received a standardized general anesthetic technique.
RESULTS:
There were no significant differences in any of the emetic outcomes orneed for rescue antiemetics between TDS and ondansetron groups inthe first 6 h after surgery.
CONCLUSION:
Premedication with TDS (1.5) mg was as effective as ondansetron (4 mg) in preventing nausea and vomiting in the early postoperative periods. Also less cost with TDS patch.
10. Tarkkila P, Torn K, Tuominen M, Lindgren L. Premedication with promethazine and transdermal scopolamine reduces the Incidence of nausea and vomiting after intrathecal morphine. Acta Anaesthesiol Scand 2015;39:983–6.
11. Pergolizzi Jr JV, Philip BK, Leslie JB, Taylor Jr R,et al Perspectives on transdermal scopolamine for the treatment of postoperative nausea and vomiting. Journal of clinical anesthesia. 2012;24:334-45.
12. Apfel CC, Zhang K, George E,et al. Transdermal scopolamine for the prevention of postoperative nausea and vomiting: a systematic review and meta-analysis. Clinical therapeutics. 2010 ;32:1987-2002.
13. Sah N, Ramesh V, Kaul B, Dalby P, Shestak K, et al Transdermal scopolamine patch in addition to ondansetron for postoperative nausea and vomiting prophylaxis in patients undergoing ambulatory cosmetic surgery. Journal of clinical anesthesia. 2009;21:249-52.
)
