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Abstract
BACKGROUND:
Breast cancer is the most common malignancy and the leading cause of cancer-related deaths among women worldwide. In Iraq, breast cancer ranks the first among the top ten malignant neoplasm affecting the community. During 2016, 897 women died from the disease, and registered as the first cause of cancer related mortality among Iraqi females (23.6%) and second to bronchogenic cancer (12.1%) among males and females, and this study aimed to evaluate the clinicopathological, immunohistochemistry features of patients with breast cancer ≤ 35 years, in comparison to those > 35 years, and the impact of age on their prognosis.
PATIENTS AND METHODS:
In this retrospective study, medical reports of 220 patients with a known breast cancer, in Baghdad Oncology Teaching Hospital/ Medical City and Babylon oncology center databases were reviewed between February 2017and February 2019. Patients were divided into two groups
RESULTS:
Patients ≤35 years whom had menarche at age ≥ 14 years old were surprisingly higher 19 (17.3%) as compared to patients >35 years 7 (6.4%).according to age, 110 patients aged ≤ 35 years and 110 patients aged > 35 years old.
Most patients at both age group had their first baby within age 20-25 years, while 30 patients (27.3%) ≤ 35 years had their first baby at age 25-29 years old, which was higher than older patients within same age group.
Most of patients presented with grade II disease in both age group ,but 21 (19.1%) of patients ≤35 had grade I disease higher than in >35 years old 1 (0.9%) which was unusual finding as most of younger patients presented with grade III disease. Positive lymph node involvement was found to be higher in 85 patients ≤35 years(77.3%), while it was positive in 61 patients (55.5%) in older than 35 years old.
HER-2 expression was higher in 23 patients (20.9%) who were ≤35 years old, while it was positive in 13 patients (11.8%) older than 35 years.
CONCLUSION:
Breast cancer among young females as proved is quite heterogeneous disease ,and the differences when compared to older females regarding tumor characteristics include clinicopathological, immunohistochemistry features suggest opportunities for further researches to deal with younger age as a distinct group.
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