Abstract

ABSTRACT:
BACKGROUND:
Inflammatory responses are involved in the initiation and progression of atherosclerotic plaques.
Myocardial Infarction (MI) is most commonly due to occlusion of a coronary artery following the
rupture of a vulnerable atherosclerotic plaque. It has been suggested that the adipose tissue may
play an important role in mediating this chronic inflammatory process. Resistin is a cysteine-rich
polypeptide that is expressed at relatively lower levels in human adipocytes but higher levels in
macrophages. Troponin is found in cardiac muscle and used for diagnosis of AMI.
OBJECTIVE:
To investigate the level of resistin and its effect on lipid profile and Troponin I levels in acute
myocardial infarction patients.
SUBJECT AND METHODS:
The study included 50 patients with AMI and forty healthy subjects as control group. In this study
resistin , lipid profile and Troponin I were measured.
RESULTS:
The levels of resistin, cholesterol, LDL-C were significantly elevated with (p<0.001), while HDLC
was significantly lower with (p<0.001), there was positive correlation between resistin with
cholesterol, LDL-C, triglyceride and VLDL, while there was negative correlation between
resistin with HDL in acute myocardial infarction.
CONCLUSION:
There was a significant increase in resistin level, in acute myocardial infarction patients and this
increase may be related to inflammation. Resistin negatively correlated with HDL and positively
correlated with triglyceride and LDL this relationship makes us consider this hormone as possible
atherosclerotic factor