Osteoarthritis is a form of arthritis that features the breakdown and eventual loss of the cartilage of one or more joints. Cartilage is a protein substance that serves as a "cushion" between the bones of the joints. Among the over 100 different types of arthritis conditions, osteoarthritis is the most common, affecting over 25 million people in the United States. Osteoarthritis occurs more frequently as we age. Osteoarthritis is abbreviated as OA or referred to as degenerative arthritis or degenerative joint disease (DJD). Osteoarthritis commonly affects the hands, feet, spine, and large weight-bearing joints, such as the hips and knees. Osteoarthritis usually has no known cause and is referred to as primary osteoarthritis. When the cause of the osteoarthritis is known, the condition is referred to as secondary osteoarthritis.
The main objective of this study is to evaluate the association between the levels of Interleukin-8 and some antioxidant in patients with OA.
PATIENTS AND METHODS:
This study was performed during the period from April 2010 to February 2011, and included 50 patients with OA according to the American College of Rheumatology ACR 1990; their age range from 40-60 years with mean age of 46.66 ± 2.83 years. These patients were matched by age and sex to 25 healthy control subjects with the mean age of 48.32 ± 2.92 years. Blood samples were taken from each individual and separated for the estimation of IL-8 and some antioxidants levels using enzyme – liked immunosorbent assay (ElIZA) technique and colorimetric method. The laboratory tests were done in Teaching Laboratories of the Medical City and the Department of Physiological Chemistry / College of Medicine University of Baghdad.
The level of IL-8 and Ceruloplasmin (CP) in serum of patients with OA was significantly higher than in serum of healthy control while the level of Glutathione (GSH) and S.uric acid in serum of OA patients was significantly higher than healthy control and there is no significant difference in level of serum albumin between the patients and control.
It is clear from this study that there is a relationship between the levels of IL-8, CP, GSH, and S.uric acid concentrations and OA while there is no relationship between S.albumin concentration and OA disease.