Abstract

ABSTRACT:
BACKGROUND :
Fine-needle aspiration (FNA) is a rapid, safe, minimally invasive, and inexpensive way of
diagnosing malignancy in women with palpable breast tumors.
This study was used the wide bore needle technique to obtain optimal results & can used instead of core needle biopsy .
OBJECTIVE:
Fine-needle aspiration cytology is a rapid, safe, inexpensive and minimally invasive technique for diagnosis of breast malignancy. This study was an attempt to use wide bore needle instead of core needle biopsy to obtain optimal results.
METHOD:
Thirty five females with breast lumps underwent FNA aspiration cytology in the department of Al-jamhuri Teaching Hospital in Mosul city. The study was achieved by using 19 gauged needle, part as routine cytology and other part as tissue block. Immunohistochemical stain for ER, PR and HER2 markers was performed on tissue blocks from 17 malignant cases.
RESULTS:
The cytology findings included 24 malignant cases (22 ductal carcinoma and 2 lobular carcinoma), 7 benign lesions and 4 suspicious cases. On the other hand, in tissue blocks the diagnosis of malignancy was given in 28 cases, 25 ductal carcinomas and 3 lobular carcinomas. Seven benign lesions ,6 were previously diagnosed as such by cytology and one suspicious case turned to be benign on wide bore needle. The four cytologically suspicious cases turned to be malignant in 3 cases and benign fibrocystic changes in the fourth case. Immunohistochemical analysis including ER, PR and HER-2 on seventeen cases of breast carcinomas. Seven out of 17 were shown positivity for ER while 3 cases were PR positive and Her2-neu was positive in 12 cases.
CONCLUSION:
It is preferred to use wide bore needle in the diagnosis of breast lesions to obtain more tissue material and optimal results. As well, to a certain extent the wide bore needle might substitute the core needle biopsy for diagnosis and immunohistochemical assessment because the latter is rather expensive and, at time is not available in our laboratories now.