Abstract

 BACKGROUND:
Knee osteoarthritis (OA) is a degenerative disease of the knee joint. There is no cure for the
disease, but some treatments attempt to slow disease progress.
Intraarticular ozone injection is increasingly being applied. In knee osteoarthritis it represents a
complementary treatment method which provides pain relief, decongestion, subsidence of bruises
(hematomas), a reduction in temperature and an improvement in motility.
OBJECTIVE:
To evaluate the analgesic effect of 4 subsequent intra-articular ozone-oxygen injections in knee
joint osteoarthritis.
PATIENTS AND METHODS:
It was a prospective, randomized clinical study, done on 30 knee joints, all patient were with
history of OA of knee joint & suffering from long standing pain & they have long history of
medical therapy. After taking patient consent, 5 weekly sessions of intra-articular 5 ml (25 μg/ml )
ozone injections were done under complete aseptic technique. Numerical Analog Pain score has
been assessed and recorded before each session.
RESULTS:
It was found that there was highly significant difference between each 2 subsequent sessions and
the p-value was below 0.01 in all times.
CONCLUSION:
Subsequent Intra-articular ozone injection had significant analgesic effect in knee joint
osteoarthritis