Midazolam is one of benzodiazepines. It is most lipid soluble as a result has a rapid onset and short duration of action, used in anesthesia for sedation or intravenous induction according to the dose used.
Is to notice if there is an effect of midazolam on heart rate in pediatric patients with using ketamine as induction agent under general anesthesia.
PATIENTS AND METHODS:
60 peadiatric patients undergoing surgery randomly allocated in 2 groups(A and B). Aneasthesia was standardized for all patients (except addition of Midazolam in sedative dose (0.03 mg/kg) i.v. preinduction to group( B). Heart rate measured preoperatively as abaseline and 5 and 15 minutes after induction.
Adding midazolam associated with a reduction in HR by an average of 10 beats/min 5 and 15 minutes after induction of anaesthesia. This effect failed to reach the level of statistical significance although it was clinically significant.
Midazolam have well known sedative effect but have no significant effect on heart rate in paediatric patients.