Abstract

ABSTRACT:
BACKGROUND:
Infection with H. pylori has been recognized as a public health problem worldwide. Studies to address the association of H. pylori infection with diabetes mellitus (DM) had yielded controversial results.
OBJECTIVE:
To figure out the association between H. pylori infection and DMtype 1 and 2 in Baquba city, Iraq .
PATIENTS AND METHODS:
This cross-sectional case control study was conducted in Baquba-Diyala province for the period from August 2015- March 2016. 82diabetic patients (67 with type 2 and 15 with type 1) and 23 healthy non-diabetic individuals were enrolled. The DM patients include 45 (54.9%) females and 37(45.1%) males. The mean age ±SD of type 2 DM patients was51.37± 10.84 years,while the mean age ±SD of patient with type 1 DMwas 23.66 ± 6.99 years. The patients were collected from the outpatient clinic of Baquba General Teaching Hospital according to the WHO definition criteria of the DM. Blood samples were collected, sera were separated and tested for the presence of anti-H. pyloriIgG antibody using the commercially available Enzyme- linked immunosorbant assay kit.Statistical analyses were done using the Statistical Package for Social Science (SPSS) Version 18, and P value < 0.05 was considered significant.
RESULTS:
The results showed that the anti- H. pylori positivity rate among patients with diabetes mellitus and controls was 35.2% and 9.5% respectively, with statistically insignificant difference (p= 0.54). The anti- H. pyloripositivity rate was slightly higher in type 2 DM than in type 1 DM (29.5 % vs 5.7 %, p=0.9).Diabetic male had insignificantly higher positivity rate compared to female ((29.5% vs26.8, p= 0.096%). Furthermore, higher positivity rate was found in the age group 30-50 years.
CONCLUSION:
The anti-H. pyloripositivity rate is insignificantly higher among diabetes mellitus patients; particularly type 2 diabetes mellitus than non-diabetic individuals in Baquba cit, Iraq .