Abstract

ABSTRACT:
BACKGROUND:
Glugose-6- phosphate dehydrogenase deficiency is the most common human enzyme deficiency in
the world andlead to hemolytic anemia as early sign.
OBJECTIVE :
To determine the age of the patient with G6PD deficiency in which can the enzyme return to
normal activity indifferent areas of Baghdad and to study if there is sex predilection for
spontaneous regeneration of the enzyme.
PATIENTS AND METHODS:
Case control study carried on patients at AL-kadhyimia teaching hospital and patientscollected
from different areas of Baghdad city during period from 1st of April 2012 to 31st of December
2012, 159 patients of G6PD disease, the range of their age 2-17years old age and 121(76%) of
them were male and 38(24%) were female. Another 100 normal children of different sex and age
range from 6-17 years were regard as control group, they were collected from different schools in
Baghdadcity ,all of them had normal enzyme activity.
RESULTS:
Age of spontaneous regeneration of G6PD wasstatistically significant becauseP value
=<0.001(highly significant)i.e. as patient becomes older ( >14year) he has a very good chance for
the enzyme to return to normal activity.
CONCLUSION:
The age of spontaneous regeneration of G6PD enzyme in children was above 14 yearsandthere is
no sex predilection.