Abstract

ABSTRACT:
BACKGROUND:
Hemolytic uremic syndrome (HUS) is important cause of acute kidney injury (AKI) and chronic kidney disease (CKD) in children. Proposed prognostic features are controversial.
OBJECTIVE:
Our objective was to study the characteristics of HUS and determine short-term outcome and risk factors for prognosis in children followed in a single center in Baghdad city.
PATIENTS AND METHODS:
We reviewed, retrospectively, the records of children with HUS seen at child welfare Teaching hospital, Baghdad( April2015- April 2017and studied outcome and some prognostic risk factors.
RESULTS:
Thirty-three children with HUS were recorded; 40% had diarrhoea positive (D+) and 60% diarrhoea negative (D−) HUS. The mean age was 47.8 40.4 months and males were 63.6%. At the acute phase seizures and hypertension were present in 33.5%, and 66.7% respectively. Severe anaemia, thrombocytopenia, and leukocytosis were present in 87.9%, 96.6%, and 27.2% respectively. Clinical and laboratory features were not significantly different in D+ and D− cases (P > 0.05 for all parameters). Dialysis was undertaken forall patients. Demographic, clinical and laboratory features were not significant risk factors for adverseoutcome. At short-term follow up (mean period ± SD of 18.54 ± 13.21 months), 42.2% had complete renal recovery, 35.4chronic kidney disease, and 24.2% died.
CONCLUSION:
In spite of institution of dialysisand supportive therapy for all patients, our data showed less favorable outcome of HUS.
KEYWORDS: Children, Hemolytic uremic syndrome, Outcome