Abstract
ABSTRACT:
BACKGROUND:
Fever occurs in about 80% of patients with hematologic malignancy during chemotherapy-induced
neutropenia. Fever during chemotherapy-induced neutropenia may be the only indication of a severe
underlying infection.
OBJECTIVE:
To determine the common types of bacterial pathogens causing febrile neutropenia and their
susceptibility to antibiotics in patients with hematological malignancies in Baghdad Teaching
Hospital.
PATIENTS AND METHODS:
50 patients with hematological malignancies and febrile neutropenia were enrolled in this cross
sectional study. All patients were sent for CBC, GUE, blood culture and sensitivity test. Other
sample cultures were sent on indication
RESULTS:
AML (42%) was the most common malignancy .Blood culture was positive in (24%).
The most common bacteria isolated by blood culture was Staphylococcal aureus (41.67%), gram
positive bacteria were predominant in hematological malignancy (62.5%), positive sputum culture
was obtained in 4(8%) of patients.
The most frequently effective antibiotic was Imipenem for gram positive infections, and Amikacin,
Imipenem and Piperacillin/Tazobactum for Gram negative infections.
CONCLUSION:
Gram positive bacteria were the most common bacteria with Staphylococcal aureus as the most
common bacterial pathogen isolates in blood culture and streptococcal pneumonia in sputum culture,
Imipenem was most commonly effective antibiotic.
Keywords
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