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The Role of Desmin in Assessing and Staging of Urothelial Carcinoma

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Document Type : Research Paper

Abstract

ABSTRACT:
BACKGROUND:
Pathological stage of urothelial carcinoma is the most important factor in determining the prognosis and the mode of therapy. Desmin antibody is used to stage urothelial carcinoma by distinguishing the muscular invasion from desmoplasia and differentiating muscularis mucosa from muscularis proprial invasion.
AIM OF THE STUDY:
To evaluate the usefulness of Desmin expression in differentiation muscularis mucosa from propria invasion and assess muscular invasion in urothelial carcinoma.
MATERIAL AND METHODS:
A retrospective study was done on 40 cases with urothelial carcinoma from the histopathology department of Teaching Hospitals and private laboratories in Mosul city, starting in January 2018 till July 2020. Their mean age was 62.1 years. All cases stained by desmin antibody.
RESULTS:
It was found that the high-grade Urothelial carcinoma is predominant, which is composed of 80%. Desmin can distinguish the muscularis mucosa from propria by at least one level of difference in the strength of the staining intensity.
CONCLUSION:
Desmin marker helps assess the stage of urothelial carcinoma by the differentiation between muscular layer of the bladder wall.
 
 

Keywords

References
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Iraqi Postgraduate Medical Journal
Volume 20, Issue 4
October 2021
Page 373-379
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