Abstract
BACKGROUND:
Hypotension is the most common complication after spinal anesthesia for patients undergoing cesarean section. Prevention and treatment of post-spinal hypotension has been frequently investigated.
AIM OF STUDY:
Our study aimed to compare the effect of prophylactic infusion of combined ephedrine and phenylephrine, ephedrine, or phenylephrine alone in prevention of maternal hypotension after cesarean section.
PATIENTS AND METHODS:
90 pregnant women that underwent elective cesarean delivery under spinal anesthesia were included and divided into: group A received an infusion of combined ephedrine and phenylephrine; group B received ephedrine infusion, and group C received phenylephrine infusion. Maternal parameters were recorded.
RESULTS:
There was an insignificant difference in demographic data among the groups. The maternal MAP shows no statistically significant difference, but the combined group shows less hypotensive episodes and less maternal side effects.
CONCLUSION:
Prophylactic infusion of ephedrine and phenylephrine combination can effectively decrease spinal anaesthesia related hypotension without any significant side effect.
10. Ueyama H, HeYL, Tanigami H et al – Effects of crystalloid & colloid preload on blood volume in the parturient undergoing spinal anaesthesia for elective cesarean section. Anaesthiology, 1999; 91: 1571-76.
11. The Effect of Prophylactic Infusion of Combined Ephedrin and Phenylephrine on Maternal Hemodynamic after Spinal Anesthesia for Cesarean Section: A Randomized Clinical Trial Simin Atashkhoie, Hojat Pourfathi, Bahman Naghipour, and Shahla Meshgi, Iran J Med Sci. 2018 ; 43: 70–74.
12. A comparative study of phenylephrine and ephedrine combination to ephedrine and phenylephrine alone for maintenance of blood pressure for caesarean delivery and their effects on foetal acid base status.Ritu Singh, Reetu Verma, VK Bhatia, Ajay K Chaudhary, Girish Chandra, 2018; 8:29-34 .
13. A comparative study of infusions of phenylephrine, ephedrine and phenylephrine plus ephedrine on maternal haemodynamics in elective caesarean sectionSabyasachi Das, Soma .Mukhopadhyay, Mohanchandra Mandal, Sukanta Mandal,1 and Sekhar Ranjan Basu, Indian J Anaesth. 2011; 55: 578–83.
14. A Randomized Double-Blinded Comparison of Phenylephrine and Ephedrine Infusion Combinations to Maintain Blood Pressure During Spinal Anesthesia for Cesarean Delivery: The Effects on Fetal Acid-Base Status and Hemodynamic Control Warwick D. Ngan Kee, Anna Lee, Kim S. Khaw, Floria F. Ng, Manoj K. Karmakar, Tony Gin, China, 2008 .
15. Comparison of Maternal and Fetal Effects of Ephedrine and Phenylephrine Infusion during Spinal Anesthesia for Cesarean Section. Sun Woo Jung, Eun Ju Kim, Byung Woo Min, Jong Suk Ban, Sang Gon Lee, Ji Hyang Lee, Korean Journal of Anesthesiology 2006;51:335-42.
16. Comparison of ephedrine-phenylephrine vs ephedrine to treat hypotension during elective cesarean section after spinal anesthesia : Mercier, V.; Roelants, F.; Gavage, L.; Lavand'homme, P. M.European Journal of Anaesthesiology: 2005; 22 :155.
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