Authors
Department of Pathology, College of Medicine/ University of Baghdad, Baghdad, Iraq.
,
Document Type : Research Paper
Abstract
BACKGROUND:
Urothelial carcinoma and prostatic adenocarcinoma are the most common tumors of genitourinary system. Both can demonstrate a broad histology or present as undifferentiated carcinoma that made the distinction of which is the primary source very difficult. In indeterminate tumor morphology, the immunohistochemical markers will assist the pathologists to avoid misinterpretation.
AIM OF THE STUDY:
To assess immunohistochemical expression of GATA3 in urothelial and prostatic adenocarcinoma with correlation to different clinicopathological parameters.
MATERIALS AND METHODS:
This retrospective study was done on formalin-fixed paraffin embedded tissue blocks from 20 urothelial CA and 20 prostatic adenocarcinoma cases. GATA3 was used and semi-quantitatively scored.
RESULTS:
90% of urothelial CA cases were GATA3 positive with 75% strong expression. While 85% of prostatic CA cases were GATA3 negative, there was no significant correlation between GATA3 expression and clinicopathological parameters except for gender in urothelial CA.
CONCLUSION:
GATA3 has a potential role to confirm the urothelial origin of the tumor in comparison to prostatic carcinoma. There was no significant correlation between GATA3 expression in urothelial carcinoma and prostatic carcinoma cases and clinicopathological parameters except for gender in the first.
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