Authors
1
Chemical Pathology, Dhi-Qar Health Directorate- Iraq.
2
Department of Biochemistry- College of Medicine/ University of Baghdad- Iraq.
,
Document Type : Research Paper
Abstract
BACKGROUND:
The assessment of the level of some biochemical parameters (liver function test, renal function test, serum ferritin and plasma D-dimer) revealed that the Covid-19 infection affected the level of them. The study aimed to demonstrate the biochemical changes of liver and renal functions tests, serum ferritin and plasma D-dimer in Iraqi patients with Covid-19 disease.
PATIENTS AND METHODS:
A retrospective cross sectional study conducted in Isolation centers for Covid-19 patients in Baghdad and AL-Najaf AL-Ashraf Governorate from July 2020 to February 2021. Forty five males and 76 females were included in this study. The exclusion criteria were patients below eighteen years old age, pregnant women, and subjects with hematological diseases, cardiovascular disease, liver diseases and renal diseases. All parameters measured by automated method by Beckman coulter Au480 chemistry analyzer.
RESULTS:
Covid-19 infection was more in females than males and it is more in post middle age (41-50 years old). In the current study, most of the biochemical parameters (AST, ALT, urea, serum ferritin, AST/ALT ratio<1 and plasma D-dimer) increased through the period of Covid-19 infection of them AST, ALT, urea and AST/ALT ratio <1 were more increased in females. The age was significantly negative and positive correlated with the activity of AST and urea concentration respectively. The gender was significantly positive correlated with AST/ALT ratio. There was no correlation between plasma D-dimer and serum ferritin with other biochemical parameters except for AST activity which was significantly positive correlated with serum ferritin.
CONCLUSION:
Most of the biochemical parameters (AST, ALT, urea, plasma D-dimer and serum ferritin) were affected by Covid-19 infection which indicated organs damage. The age and gender were affected the activity and level of some biochemical parameters (AST and Urea were significantly negative and positive correlated with age respectively and AST/ALT ratio was significantly positive correlated with gender).
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