Abstract
BACKGROUND:
Meningiomas are the most common tumor of central nervous system with a higher prevalence in women. Clinical and epidemiological data reveal that meningiomas are hormone sensitive tumors and they have been found to express hormone receptors.
Meningiomas are common slow growing primary intracranial neoplasms attached to the dura matter and are composed of neoplastic meningiothelial cells and these tumors fall in to WHO grades I, II and III.
AIM OF STUDY:
The aim of this study is to determine the progesterone receptor status in meningiomas by using specific monoclonal antibody and to evaluate the effect of age, gender, tumor grade, location and histological types on hormone receptor status.
MATERIALS AND METHODS:
This is a retrospective study of fourty patients who were diagnosed histopathologically as meningioma.
Formalin fixed, paraffin embedded tissue blocks were collected from pathology departments of Ghazi AL Hariri teaching hospital, for the period from May 2015 to June 2020 and from neurosurgery hospital, for the period from January 2018 to December 2019.
All the clinical details including age, gender, location, histological type and pathological grade have been taken from the patients archive files.
Two sections of 5 µm were taken from each block, the first was stained with hematoxylin and eosin stain (H&E) for histological revision, the other section was stained immunohistochemically for progesterone receptor (PR).
RESULTS:
Fourty patients were studied 27(67. 5%) female and 13(32.5 %) male, age was ranging from 12-70 years with a mean of 49.47 years. Female to male ratio of 2.07:1.Cerebral site was the dominant site of lesion (60%), followed by olfactory groove, parasagittal site (10% for both of them), orbital, sphenoid site (7.5% for both of them) and spinal site (5%).
Regarding histopathological types of meningioma, meningiothelial type was the most common (32.3%), followed by Atypical (20%), Angiomatous (15%), Anaplastic, fibroblastic, psammomatous and transitional (7.5 for each of them), then Anaplastic papillary (2.5%).
In all stained slides of meningiomas, there were positivity for PR (62.5%) with different scores from +1(20%), +2(17. 5%) and +3(25%).
There is a significant statistical correlation between the grade of meningioma (p=0.003), histological types (p=0.014) and PR expression.
There is no significant statistical correlation between age, sex, location and PR expression.
CONCLUSION:
There is a significant correlation between tumor grade, histological types and PR expression and PR immunohistochemical staining is a reliable test when used to predict a low-grade meningioma.
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