Authors
1
Health Directorate of Wasit, Al-Aziziya General Hospital, Wasit, Iraq.
2
Gynecology and Obstetrics, Retired Professor
Abstract
BACKGROUND:
Preeclampsia is associated with ischemia and increased oxidative stress in the placenta. Ischemia-modified albumin has been widely accepted as a serological biomarker in preeclampsia.
OBJECTIVE:
To evaluate the relationship between maternal serum and cord blood ischemia modified albumin levels with preeclampsia severity and neonatal outcome.
PATIENTS AND METHODS:
This study includes 90 pregnant women who were divided into three groups: Group 1 includes 30 pregnant women with severe preeclampsia. Group 2 includes 30 pregnant women with mild preeclampsia. Group 3 includes 30 normotensive pregnant women with uncomplicated pregnancy considered as control group. The three groups were matched for age and gestational age. Maternal blood sample and neonatal cord blood were collected from all groups and level of ischemia Modified Albumin concentration was measured by kit uses enzyme – linked immune sorbent assay.
RESULTS:
The mean of maternal serum and cord blood Ischemia modified albumin of group A and Group B were significantly higher than that of group C (P- value =0.001), The study shows significant inverse correlation with neonatal birth weight and level of ischemia modified albumin within the study groups.
CONCLUSION:
Maternal serum and cord blood Ischemia Modified Albumin levels were significantly higher in severe preeclampsia than in mild and uncomplicated normotensive pregnant women, also their levels were inversely correlated with neonatal birth weight.
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