Abstract

BACKGROUND:
Breast cancer is the most common cancer. The commonest type of breast cancer is invasive ductal carcinoma. Fibroadenoma a common benign lesion occur in about one in four women. Annexin-A5 is a tumor marker which is a member of the calcium phospholipid binding protein family that could promote tumorigenesis and progression in certain types of cancers.
OBJECTIVE:
Study the expression of AnnexinA5 in breast cancer and fibroadenoma and correlate the result of study with the clinico-pathological parameters.
PATIENTS AND METHODS:
Comparative case - control study included two groups, group A 30 patients with breast cancer and group B 30 patients with fibroadenoma. Each block of all groups of cases was sliced into two slides (one for Hematoxylin and eosin and the other for immunohistochemistry study). 
RESULTS:
AnnexinA5 expression in fibroadenoma was found in 100% of cases which is greater than its expression in invasive ductal carcinoma (70% of cases). There was no significant correlation between A5 expression & age of patients, histologic grade, perineural invasion, vascular invasion and necrosis in invasive ductal carcinoma.
CONCLUSION:
According to the results of present study it was concluded that there is a significant expression of AnnexinA5 in fibroadenoma correlated with age, and non-significant expression of AnnexinA5 in invasive ductal carcinoma in correlation with age, grade, necrosis, vascular and perineural invasion.