Authors
1
Al-Rusafa Health Directorate/Al-Fahama PHC, Baghdad, Iraq
2
College of Medicine/ Al-Nahrain University, Baghdad, Iraq
,
Document Type : Research Paper
Abstract
BACKGROUND:
Several line of evidence have indicated the role serum thyroglobulin (Tg) concentrations in differentiating malignant from benign thyroid cancer. However, such a role in differentiating follicular from papillary thyroid carcinoma still needs more studies.
OBJECTIVE:
To evaluate the prognostic value of preoperative serum Tg level in differentiation between follicular and papillary thyroid cancer in patients undergoing thyroidectomy.
PATIENTS AND METHODS:
This is a retrospective single center study including 50 patients diagnosed with thyroid carcinoma and scheduled to have total thyroidectomy. Patients‟ demographic and final histopathology reports were obtained. Serum Tg was measure preoperative.
RESULTS:
Papillary thyroid carcinoma (PTC) was reported in 38 patients (76%), while the other 12 patients (24%) were found to have follicular thyroid carcinoma (FTC). The sensitivity and specificity of Tg in detection of PTC was 60.53% and 33.33%. While the sensitivity and specificity of Tg was 33.33% and 60.52% in predicating FTC. Hypocalcemia was the most common complication, up to 10%. There was no significant relationship between any of the included demographic or clinical factors and the type of cancer or the development of complications.
CONCLUSION:
Thyroglobulin has a moderate sensitivity for detection PTC (60.53%), while it has poor sensitivity for detection FTC (33.33%).
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