Authors
1
Ministry of Health
2
Central Teaching Hospital of Pediatric
3
Pediatric Consultant Pediatric Gastroenterology College of Medicine/ Baghdad .
,
Document Type : Research Paper
Abstract
Background:Celiac disease is an immune-mediated enteropathy triggered by the ingestion of gluten in genetically susceptible individuals. Gluten is the major protein component of wheat, rye, and barley, the major predisposing genes are the HLA-DQ2 and DQ8 genotypes found in at least 95% of patients. Achieving early diagnosis of coeliac disease is critical to ensuring good lifelong health and providing children with the ability to thrive .
Objective:To demonstrate the profiles of coeliac disease (the way in which coeliac disease present , to find out age and sex distribution , endoscopical and histopathological finding) and to analyze the correlation of HLA haplotypes with clinical and laboratory profiles of coeliac disease in children.
Patients and methods:A retrospective study was done on forty children and adolescents of ≤14 years old of age, with clinical diagnosis of celiac disease, whom attended the pediatric gastroenterology outpatient clinic of Children Welfare Teaching Hospital in Baghdad city.
Results:
The mean age was 8.1 year. Female were 21(52.5%), male were 19(47.5%). Short stature was the commonest chief complaints in 20 patients (50%). The commonest histopathological finding Marsh 3 was the commonest in 27(67.5%) patients.
HLA typing system: 15 patients labeled as DQ2 (37.5%), 12 patients labeled as DQ8 (30%), 12 patients were having both DQ type (30%). The dominant haplotype was DQB1*02, The higher proportion of those with DQ2 or DQ8 or both aged 5-10 years (DQ2 46.7% , DQ8 41.7% , both 50.0%).. Anti_tissuetransglutaminase IgA was positive in all of those having both DQ2 and DQ8 100%.
Conclusion:This result showed that patient with sever histopathology ( Marsh 3 ) carried HLA -DQ risk alleles and in other side Marsh 1 or 2 carried low or no HLA-DQ risk alleles, patient with at least one DQB1*02 allele showed high expression of clinical and histological presentation of coeliac disease.
Keywords
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Celiac,,
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,،,؛disease,,
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,،,؛humen,,
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,،,؛leukocyte,,
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,،,؛antigen haplotype
Full Text
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