Authors
1
Specialist Urologist, Shaheed Mohamed Baker Alhakeem General Hospital , Iraq
2
Consultant Urologist, AL-Yarmook Teaching Hospital, Baghdad, Iraq
,
Document Type : Research Paper
Abstract
BACKGROUND:
The most effective treatment for muscle-invasive bladder cancer and non-muscle invasive bladder cancer with highest risk of progression, is Radical cystectomy and urinary diversion. This operation carries a high risk of complications of multiple types that can affect not only the urinary system but also other systems.
OBJECTIVE:
This study analyzes the early complications (within 30 days) of Radical
Cystectomy and urinary diversion, using a standardized classification system i.e. Clavien-Dindo classification system.
PATIENTS AND METHODS:
This is a combined retrospective and prospective study analyzing the early complications of RC. We review the early (30 days) post-operative period retrospectively for the previous cases and monitor this period, prospectively, for the coming cases at Al-Yarmook teaching hospital in Baghdad, Iraq from October 2017, to October 2019. We record the preoperative variables and postoperative complications in a systematic method using Clavien-Dindo classification system and the relationship between them.
RESULTS:
Twenty three patients are included in the study with a mean age 65.1 year. Urinary diversion types are cutaneous ureterostomy (9 patients) ileal conduit (10 patients) and orthotopic bladder (4patients). Most of the postoperative complications are minor (CD grade I and II) (73.3%).
The predominant grade of complications are grade II (46.4%), while the least grades are grade IVb (3.5%) and grade V (3.5%).
CONCLUSION:
Radical cystectomy and urinary diversion for urinary bladder cancer carries a high risk of complications, but fortunately, most of these complications are minor and of low grade according to Clavien-Dindo classification system. Applying this classification system in the early complications of radical cystectomy allows rapid review of complications by researchers.
- Urological neoplasia. In: John Reynard, Simon F Brewster, Suzanne Biers, and Naomi Laura Neal. Oxford Handbook of Urology. Fourth editon. Oxford University Press New York; 2019:251-406.
- Guzzo TJ, Christodouleas JP and Vaughn DJ. Management of Metastatic and Invasive Bladder Cancer. In: Partin AW, Dmochowski RR, Kavoussi LR,et al. Campell-Walsh-Wein urology. 12thV3. Elsevier, Philadelphia; 2020:3112-32.
- Witjes JA, Bruins M, Cathomas R, et al. Muscle-invasive and Metastatic Bladder Cancer. In: European Association of Urology 2021 edition Guidelines: 2021:1-94.
- Navai N, and Colin PN. Surgical Management of Bladder Cancer: Transurethral, Open, and Robotic. In Partin AW, Dmochowski RR, Kavoussi LR,et al. Campell-Walsh-Wein urology. 12th edition.V3. Elsevier, Philadelphia; 2020:3133-59.
- Skinner EC, Daneshmand S. Orthotopic Urinary Diversion. In: Partin AW, Dmochowski RR, Kavoussi LR,et al. Campell-Walsh-Wein urology. 12th edition.V3. Elsevier, Philadelphia; 2020:3232-57.
- Clavien P, Sanabria J, Strasberg S. Proposed classification of complication of surgery with examples of utility in cholecystectomy. Surgery 1992; 111:518–526.
- Dindo D, Demartines N, Clavien PA. Classification of Surgical Complications: A New Proposal with Evaluation in a Cohort of 6336 Patients and Results of a Survey. Ann Surg 2004;240: 205 -213.
- Donat SM, Siegrist T, Cronin A, et al. Radical cystectomy in octogenarians-does morbidity outweigh the potential survival benefits?. Journal of Urology 2010;183: 2171-77.
- Takada N, Abe T, Shinohara N, et al. Peri-operative morbidity and mortality related to radical cystectomy: a multi-institutional retrospective study in Japan. BJU International 2012; 110.
- Novara G, De Marco V, Aragona M, et al. Complications and mortality after radical cystectomy for bladder transitional cell cancer. Journal of Urology 2009 S;182:914-21.
- Patidar N, Yadav P, Sureka S. K, et al. An audit of early complications of radical cystectomy using Clavien-Dindo classification. Indian Journal of Urology 2016;32:282–87.
- Hautmann R E, De Petriconil RC. Lessons Learned From 1,000 Neobladders: The 90-Day Complication Rate. Journal of Urology 2010;184:990-94.
- Shabsigh A, Korets R, Vora KC. Defining Early Morbidity of Radical Cystectomy for Patients with Bladder Cancer Using a Standardized Reporting Methodology. European urology 2009; 164–176.
- Schiavina R, Borghesi M, Guidi M, et al. Perioperative complications and mortality after radical cystectomy when using a standardized reporting methodology. Clinical Genitourinary Cancer 2013; 11:189-97.
- Roghmann F, Trinh QD, Braun K, et al. Standardized assessment of complications in a contemporary series of European patients undergoing radical cystectomy. International Journal of Urology 2014; 21:143-49.
- De Nunzio C, Cindolo L, Leonardo C, et al. Analysis of radical cystectomy and urinary diversion complications with the Clavien classification system in an Italian real life cohort. European Journal of Surgical Oncology 2013; 39:792-98..
- Abe T, Takada N, Shinohara N, et al. Comparison of 90-day complications between ileal conduit and neobladder reconstruction after radical cystectomy: A retrospective multiinstitutional study in Japan. International Journal of Urology 2014;21:554–59.