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Association of Antiphospholipid Antibody and Vitamin D in Women Suffering from Recurrent Pregnancy Loss

    Authors

    • Serri Adnan Yousif 1
    • Abdulrazak H. Alnakash 2

    1 Al-Elwiya Maternity Teaching Hospital, Baghdad, Iraq

    2 Obstetrician and Gynecologist Alkindy College of Medicine University of Baghdad Al-Elwiya Maternity Teaching Hospital

,

Document Type : Research Paper

10.52573/ipmj.2025.143750
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Abstract

Background: Recurrent pregnancy loss is a heterogenous reproductive problem with multiple etiologies. Antiphospholipid antibody has been associated with recurrent miscarriage. Vitamin D3 helps to support successful implantation through through immunological action. Vitamin D3 deficiency highly associated with recurrent miscarriage.
Aim of study: To find association between antiphospholipid antibody and vitamin D3 (1, 25 dihydrocholecalcifrol) in women with recurrent pregnancy loss.
Patients and methods: A comparative cross sectional study done at Al-Elwiya Maternity Teaching Teaching Hospital in Baghdad including A 58 participants suffering from recurrent miscarriage and another 58 control group. Vitamin D3 level and antiphospholipid antibody were analyzed and data have arranged for analysis.
Results: Vitamin D3 was found to be low in 96.6% of women with recurrent miscarriage the mean was (11ng/ml) which is significantly lower than mean vitamin D3 of the control group (37.6 ng/ml (p

Keywords

  • recurrent pregnancy loss,,
  • ,،antiphospholipid antibody,,
  • ,،vitamin D deficiency

Main Subjects

  • Gynaecology and Obstetrics
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References
  1. Kolte AM, Bernardi LA, Christiansen OB, Quenby S, Farquharson RG, Goddijn. Terminology for pregnancy loss prior to viability: a consensus statement from the ESHRE special interest group, early pregnancy. Human Reprod 2015;30:495.
  2. The practice committee of the American society for reproductive medicine. Evaluation and treatment of recurrent pregnancy loss, a committee opinion. ASRM 2012; 98:1103-10.
  3. RCOG guidelines the investigation and treatment of couples with recurrent first trimester and second trimester miscarriage. RCOG Green-top Guideline 2011 No. 17.
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  7. Zhao ,  Wei  X. ,  Yang X. A novel update on vitamin D in recurrent pregnancy loss   (Review): Mol Med Rep. 2021; 23:382.
  8. Upadhyay RS, Fonseca MN. Study of incidence of antiphospholipid antibody syndrome and low vitamin D levels as an etiological factor in recurrent pregnancy loss and their correlation. Int J Reprod Contracept Obstet Gynecol 2016;5:3339-42.
  9. Mohammed AK. AL-Qani VHA. Association between maternal serum vitamin D and early pregnancy spontaneous abortion in Iraqi women. Asian J Pharm Clin Res 2018;11:432-34.
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  1. Al Samarrai AA, Hilmi FA, Al-Allawi NA, Murad AF. Antiphospholipid antibodies in iraqi women with recurrent mid-trimester abortions. J Lab Physicians 2012; 4:78–82.
  2. Orbach H, Zandman-Goddard G, Amital H, Barak V, Szekanecz Z, Szucs G, et al. Novel biomarkers in autoimmune diseases: prolactin, ferritin, vitamin D, and TPA levels in autoimmune diseases. Ann N Y Acad Sci 2007;1109:385–400.
  3. Agmon-Levin N, Blank M, Zandman-Goddard G, Orbach H, Meroni PL, Tincani A, et al. Vitamin D: an instrumental factor in the anti-phospholipid syndrome by inhibition of tissue factor expression. Ann Rheum Dis 2011;70:145–50.
  4. Andersen LB, Jørgensen JS, Jensen TK, Dalgård C, Barington T, Nielsen J, et al. Vitamin D insufficiency is associated with increased risk of first-trimester miscarriage in the Odense Child Cohort. Am J Clin Nutr 2015;102:633-38.
  5. Hou W, Yan XT, Bai CM, Zhang XW, Hui LY, Yu XW. Decreased serum vitamin D levels in early spontaneous pregnancy loss. Eur J Clin Nutr 2016; 70:1004–8.
  6. Al-Saigh NJ, Al-Safi AM. The Effects of Vitamin D and Calcium levels On Pregnant Women with Hyperemesis Gravidarum. IOSR Journal of Dental and Medical Sciences (IOSRJDMS) 2018; 17:73-79.
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Iraqi Postgraduate Medical Journal
Volume 24, Issue 1
January 2025
Page 92-97
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APA

Yousif, S., & Alnakash, A. (2025). Association of Antiphospholipid Antibody and Vitamin D in Women Suffering from Recurrent Pregnancy Loss. Iraqi Postgraduate Medical Journal, 24(1), 92-97. doi: 10.52573/ipmj.2025.143750

MLA

Serri Adnan Yousif; Abdulrazak H. Alnakash. "Association of Antiphospholipid Antibody and Vitamin D in Women Suffering from Recurrent Pregnancy Loss". Iraqi Postgraduate Medical Journal, 24, 1, 2025, 92-97. doi: 10.52573/ipmj.2025.143750

HARVARD

Yousif, S., Alnakash, A. (2025). 'Association of Antiphospholipid Antibody and Vitamin D in Women Suffering from Recurrent Pregnancy Loss', Iraqi Postgraduate Medical Journal, 24(1), pp. 92-97. doi: 10.52573/ipmj.2025.143750

VANCOUVER

Yousif, S., Alnakash, A. Association of Antiphospholipid Antibody and Vitamin D in Women Suffering from Recurrent Pregnancy Loss. Iraqi Postgraduate Medical Journal, 2025; 24(1): 92-97. doi: 10.52573/ipmj.2025.143750

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