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Bone and growth status in children with epilepsy: A hospital bases study

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Document Type : Research Paper

Abstract

Background: Children with epilepsy have a high burden of physical comorbidity, and they experience poor long-term medical outcomes even after remission of their epilepsy. Little is known about types of these comorbidities and their occurrence in children epilepsy in Iraq.
Objectives: the aim of this study to assess bone and growth status in children with epilepsy.
Patients and methods: a cross sectional case-control study was conducted in Children Welfare Teaching Hospital, in the period from November 2018 to October 2019. The study included 40 children diagnosed with epilepsy and another 40 healthy children, age- and sex-matched. The following parameters were measured in both groups: body weight, height, body mass index (BMI), bone mineral density (BMD) and vitamin D level.
Results: In the epileptic children group, 28(70%) males and 12 (30%) females were reported. The predominant epilepsy type was focal 30children (75%). Among the epileptic children. Sixteen (40%) epileptic patients were placed on monotherapy treatment, while 24 (60%) were placed on polytherapy The level of Alkaline Phosphatase and phosphorus level was significantly higher in epileptic patients than in controls while there were no significant difference in calcium levels between patients and control groups. On the other hand, vitamin D found to be lower in epilepsy children with statistical significance. The growth parameters (weight, height and body mass index)show no significance between patent and control groups, The standard normal distribution(Z-score)of DXA scan also show no significance in both groups.
Conclusion: The children with epilepsy and on treatment with AEDs are at higher risk of hypovitaminosis D, There were no significant radiological changes (measured by DXA scan) in the epileptic children placed on AEDs for at least one year, in comparison to the healthy children.

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Min L, Chunyan W & Biaoxue R. Effects of valproic acid on skeletal metabolism in children with epilepsy: A systematic evaluation and metaanalysis based on 14 studies. BMC Pediatrics, 2020; 20:97. 2-12. https://doi.org/10.1186/s12887-020-1984-7.

Iraqi Postgraduate Medical Journal
Volume 24, Issue 1
January 2025
Page 52-60
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