Authors
1
clinical pharmacist in the children welfare teaching hospital
2
Gastroenterology & Hepatology Teaching Hospital, Medical City -,Ministry of Health and Environment, Baghdad, Iraq
3
University of AL-Kafeel-College of Pharmacy, Iraq
,
Document Type : Research Paper
Abstract
Abstract
Background: The increasing prevalence of antibiotic-resistant strains of Helicobacter pylori contributed to reduce the effectiveness of the first-line standard therapy. Consequently, it is necessary to identify alternative regimens that provide better or comparable efficacy and safety.
Objective: Compare the efficacy and tolerability of 10days levofloxacin-based triple therapy versus clarithromycin-based triple therapy as a first-line eradication regimen of Helicobacter pylori.
Patients and methods: This is an open label observational comparative study. A total of 100 patients with Helicobacter pylori infection were selected; 50 patients were taking 10 day levofloxacin-based triple therapy and the other 50 patients were on 14 day clarithromycin based triple therapy. Eradication rate and adverse effects were evaluated.
Results: Helicobacter pylori eradication rates were: levofloxacin group 74%, and clarithromycin group 54%. There were a statistically significant differences in the efficacy between the two regimens (p value < 0.05). In addition, no relevant differences in adverse effects were demonstrated. There were no significant relationship between Helicobacter pylori eradication and gender, age, or smoking.
Conclusion: This study showed that levofloxacin-based triple therapy is significantly more effective than clarithromycin-based therapy in the eradication of Helicobacter pylori infection but it does not reach the recommended eradication threshold.
Keywords: Antibiotic resistance, Clarithromycin, Eradication rate, Helicobacter pylori, Levofloxacin.
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