Abstract

Abstract:

Background:

Hypothyroidism is a syndrome resulting from deficiency of thyroid hormones leading to general slowdown of many metabolic processes

Objectives:

This study was designed for investigating the occurrence of type 2 diabetes mellitus among sample of patients with hypothyroidism, as well as Investigate the relationship between fasting serum glucose and glycated hemoglobin levels with thyroid stimulating hormone, free triiodothyronine and free thyroxine

Patients and Methods:

This is a comparative cross section study include 80 subjects was taken, 40 of them as patients diagnosed with clinical hypothyroidism who are on treatment. The remaining 40 apparently healthy individuals who served as a control group. The diagnosis of clinical hypothyroidism was depending on serum thyroid stimulating hormone level of more than 4.2 Ulu /ml with low levels of free thyroxine and free tri-iodothyronine.

Results:

The mean values for the TSH levels of patients group (4.10 ± 3.25 µIU/ml) which was significantly higher than values of controls (1.74 ± 1.14, p µIU/ml < 0.001). Also, mean values for fasting serum glucose (103.68 ± 21.06 mg/dl, p < 0.001) and HbA1c (6.27 ± 1.18 %, p < 0.001) of hypothyroidism patients were significantly increased in comparison to these of control (86.23 ± 9.32 mg/dl, 5.28 ± 0.35 %, respectively).

Conclusion:

Overt hypothyroidism is related with an increased risk of type 2 diabetes mellitus and measurement of glucose indices needed to be included in hypothyroid investigations. Progression the prediabetes to diabetes seems more prominent in presence of uncontrolled hypothyroidism.