Abstract

Background:

Vitiligo is chronic autoimmune disease characterized by pale white patches developing on the skin caused by lack of melanin pigment which produced by melanocytes. Most common autoimmune disease association with vitiligo is autoimmune thyroid disease that characterized by presence of autoantibody (anti-thyroperoxidase, anti-thyroglobulin) in serum of vitiligo patients.

Aim of study:

Detection of serum anti-thyroperoxidase and anti-thyroglobulin antibodies in patients with non-segmental vitiligo.

Subject and Methods:

Serum level of Anti-thyroperoxidase and anti-thyroglobulin antibodies were assessed in 50 non segmental vitiligo patients in the dermatology Consultation Clinic of IMAM ALSADIQ Teaching Hospital / Babil Health Directorate compare with 30 apparently healthy control, their age and sex matched to the patients’ group, number of males in this study was 46 (57.5%) and female were 34 (42.5%)., using enzyme linked immunosorbent assay (ELISA) technique in the medical city\teaching laboratories\immunity unit.

Results:

Found significant association between positive anti –thyroperoxidase antibody and vitiligo patients p value 0.036, the rate of anti-TPO positive in males (80 %) more than females (20%) p value=0.058 and no significant association between positive anti – thyroglobulin antibody and vitiligo patients p value 0.0596. Both antibodies were elevated in same patient .

Conclusion:

Both antibodies could be used as screening test to autoimmune thyroid diseases in vitiligo patients.