Abstract
Background: Polycystic ovarian syndrome (PCOS) is an endocrine abnormality of the females, the anovulation, hyperandrogenism, infertility, and metabolic dysfunctions which are the main characteristic features of this disease, the elevated of serum uric acid is linked to metabolic disease as PCOS .
Objectives: To estimate the prevalence of hyperuricemia in in females of polycystic ovarian syndrome with and without insulin resistance and compare serum level of uric acid in patients of polycystic ovarian syndrome with and without insulin resistance.
Methods: Cross-sectional comparative study, non-probability convenience sampling was conducted at Out-patient's department of Gynecology in Baghdad Medical City, from March 15th till September 15th 2024. The study tools used measuring serum level of uric acid and HOMA-IR (homeostatic model assessment-insulin resistant) which is the gold standard in assessment of insulin resistance. Also used questionnaire encompassed two parts: part one cover socio-demographic of study participants and part two used Rotterdam criteria for diagnosis of polycystic ovarian syndrome (PCOS).Inclusion criteria include all patients in the age group of 20-40 years diagnosed with polycystic ovarian syndrome. Exclusion criteria are females of polycystic ovarian syndrome with and without insulin resistance and had hypertension, coronary heart disease, diabetes mellitus, cushing's syndrome, renal diseases, liver cirrhosis, women who are pregnant, lactated ,smoker, taken vitamin supplementation and medications such as (diuretic, hormonal, hypoglycemic) had been also excluded.
Results: The study showed that serum level of uric acid was highest among polycystic ovarian syndrome with insulin resistance 78.1% with P.value 0.008 and there was statistically significant association.
Conclusions: More than two third of PCOS with insulin resistance had increase in serum level of uric acid and approximately less than one third of PCOS without insulin resistance had increase serum level of uric and there was significant association.
Main Subjects
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