Abstract

ABSTRACT:
BACKGROUND:
Ischemic heart disease is the leading cause of death among adults. Broad based studies that include all
ED patients who received an ECG for the evaluation of chest pain syndromes found that 5% of these
patients were ultimately diagnosed with acute myocardial infarction (AMI) and an additional 10% had
non-AMI acute coronary syndromes (ACS). Thus, 85% of patients have non-ACS causes for their
symptoms.
OBJECTIVE:
To study the relation between the level of cardiac troponin I and creatine kinase (MB) in Acute
Myocardial infarction.
SUBJECT AND METHOD:
The present study was designed to investigate changes in serum cardiac biomarkers in patients with
acute myocardial infarction. The present study consists of 61 patients who were admitted to the hospital
with acute myocardial infarction. Serum levels of cardiac troponin I (cTnI) and creatine kinase (MB)
were determined on day 1 (within24 hours) and the 3rd day after acute myocardial infarction. Serum
cardiac biomarkers were compared between day 1 of acute myocardial infarction and the 3rd day after
the acute myocardial infarction with healthy subjects (control group). All measurements were taken
through September 2009 to April 2010 in department of medical and molecular biotechnology/
Biotechnology Research Center/ Al-Nahrain university and Ibn Al-Nafees Hospital Department of
Clinical Chemistry and Coronary Care Unit. Cardiac troponin I (cTnI) and CK-MB were measured by
using microtitre plate ELISA method, absorbance is measured spectrophotometrically at 450 nm.
Levels of serum cTnI and CK-MB for smoker patients who suffered from MI and other
diseases(diabetes mellitus, and hypertension) (group 4) higher than levels for patients who complained
from MI in addition to other diseases(group2), group 2 higher than levels for smoker patients who
suffered from MI (group 3) and group 3 higher than levels for patients who complained from only MI
(group 1).
RESULTS:
Results showed significant (p<0.01) decreases observed for the levels of cTnI in group 4 with group 1
and group 2 with group 1, and significant (p<0.05) decreases in group 4 with group 3. Significant
(p<0.05) decreases were observed for the levels of CK-MB in group 4 with group 1.
CONCLUSION:
Myocardial infarction patients with diabetes mellitus , hypertension and smoking suffer increase levels
of cTnI and CK-MB. This proved that cardiac risk factors increase risk for heart injury. However, such
results must be considered during the evaluation of the results of cardiac biomarker in patients of MI .