Abstract

ABSTRACT:
BACKGROUND:
Lactobacilli are ubiquitous in the environment and in human body. They widely used as probiotic therapeutic agents. However, several authors reported that this bacteria may cause several serious infections in various parts of human body.
OBJECTIVE:
This work is aimed to illustrate the histopathological effect of lactobacilli in murine spleen which play a major role in the immune system.
MATERIALS AND METHODS:
Three Lactobacillus isolates (namely, L. bulgaricus, L. plantarum and L. acidophilus) were isolated form yogurt, vinegar and vagina, respectively. These isolates were injected intraperitoneally in mice in a dose 1.5 X 108 CFU/ml.
RESULTS:
Several histopathological changes were caused by lactobacilli represented by degeneration, necrosis, presence of haemosidrin and macrophages and lymphoblasts.
CONCLUSION:
This non-pathogenic bacteria was able to cause severe damage to the spleen of mice.