Abstract

ABSTRACT:
BACKGROUND:
There is a suggestion that abnormal coronary physiology may be exist early in the course of idiopathic dilated cardiomyopathy (IDC), and is likely to play an important role in the pathogenesis and progression of the myopathic state in such patients. With regard to lipid profile, high-density lipoprotein cholesterol (HDL-C) particle enhances NO production and improves endothelium relaxation.
METHODS:
This study included 50 patients aged 19-72 years (13 females and 37 males) with IDC and 23 healthy controls aged 29 to 60 years (9 females and 14 males). Lipid profile, should be at least 12 hours fasting, including serum total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triglyceride (TG) were evaluated in these two groups. Measurements of some of echocardiographic parameters including left ventricular (LV) systolic and diastolic diameters, and LV ejection fraction (LVEF) in IDC patients, and correlate its values with each one of the above lipid parameters in order to define the more predictor lipid parameter in evaluating the structure and function of the heart.
RESULTS:
The mean values of serum total cholesterol and LDL-C were insignificantly higher in patients with IDC patients than in controls. The mean of serum HDL-C was significantly low in IDC group against controls (P< 0.001). The mean (± SEM) serum triglyceride TG levels in patients with IDC was significantly increased when they were compared to that of normal controls (P< 0.05). An important inverse relation was observed between serum levels of HDL-cholesterol and LV diastolic diameter values (r= - 0.29, P< 0.039) as well as between HDL-cholesterol levels and LV systolic diameter values (r= - 0.33, P< 0.02). A borderline significant positive correlation between serum concentrations of HDL-cholesterol and the values of EF % was also shown in the IDC patients
(r= 0.28, P< 0.05).
CONCLUSION:
The result of this study may point to the role of HDL-C in contribution to the LVdilatation and myocardial dysfunction (heart failure) in IDC.