Abstract

ABSTRACT:
BACKGROUND:
The objective of this study is to shed more light on the role of trace metals and their mode of action in hyperthyroidism. The content of the trace elements (Zn, Cu, Mn, and Se) in the serum of patients was determined and compared to that of normal subjects.
METHODS:
Ninety eight (98) patients with hyperthyroidism were participated in this study and fifty normal healthy persons were taken as control. Serum zinc and copper were determined using flame atomic absorption spectrophotometer while serum manganese and selenium were estimated using flameless atomic absorption spectrophotometer technique.
RESULTS:
The study showed that serum zinc and selenium level of hyperthyroidism patients were significantly lower (p<0.05) than the level in normal subjects. While a significant increase in serum copper level was demonstrated in patients as compared with that of the normal subjects. The results showed no significant difference between the groups (p>0.05) in serum manganese.
CONCLUSION:
The present study confirmed a significant changes in the levels of serum Zn, Cu, and Se in hyperthyroidism patients and these changes may be related to pathophysiology of thyroid disease