Abstract

ABSTRACT : BACKGROUND : For decades there has been a discussion whether thyroid disorders could cause gallstone disease . Particularly, there are several explanations for a possible relation between hypothyroidism and gallstone disease , these explanations include the known link between thyroid failure and disturbances of lipid metabolism that may consecutively lead to a change of the composition of the bile , motility of biliary tract and it's effect on sphincter of Oddi . OBJECTIVE: To show the relation between serum levels of thyroid stimulating hormone (TSH) and cholesterol and types of gallstone . PATIENT AND METHOD : A prospective analysis of 150 cases with cholecystectomy , were studied in Al _ Sadar teaching hospital in AL _ Najaf goverment between 1st of January 2008 till end of December 2008 , for each studied patient with gall stone serum was taken for measuring the levels of TSH and cholesterol , stone was taken after cholecystectomy and sent for chemical analysis. RESULTS : There was a remarkable gender difference with predominance of female gender as it constitutes 132 (88%) versus 18 (12%) males . Abnormal high levels of serum TSH and cholesterol were reported in 12 cases ( 8% ) and in 15 cases (10% ) respectively . Types of gallstones , were cholesterol stones in 95 cases (63%) , pigmented stone in 33 cases (22 %) and mixed stone in 22 cases (15%) . CONCLUSION : There was relationship between high serum levels of TSH and cholesterol with types of gallstones