Abstract

ABSTRACT :
BACKGROUND :
Adenosine deaminase ADA catalyzes the deamination of adenosine in purine metabolism . Adenosine deaminase deficiency is an inborn error resulting in immunodeficiency condition . clinical interest in this enzyme has been revived by the discovery of a syndrome of severe humoral and cellular immunodeficiency associated with deficiency of ADA in somatic erythrocyte cell .
AIM OF STUDY:
The aim of present study is conducted to find the relationship between human hyperthyroid activities and immune etiology in graves disease.
MATERIALS AND METHODS :
Forty individuals with hyperthyroidism autoimmune state were included in this study in comparison with forty normal persons .
Thyroid hormones levels were estimated by HPLC and serum ADA specific activity was estimated using spctrophotometric method at 265 nm . Serum protein value was determined by Bradford method .
RESULTS :
Serum ADA activity was measured for 40 hyperthyroid patients as well as 40 normal individuals . The mean activity of ADA in patients was higher than in the controls . A significant increase in T3 / T4 ratio and level of TSH were noticed .
CONCLUSION :
A positive correlation between thyroid level and ADA enzyme activity was noticed .