Abstract

ABSTRACT: BACKGROUND: To evaluate complement activation (C3) levels in all forms of acute coronary syndrome (ACS) and to find whether there is any significant changes in C3 concentration at the 1st and 4th day after admission and its relation to clinical outcome. OBJECTIVE: Comparing the degree of complement activation (C3 level) between ACS and stable pectoris.To know whether there is any significant difference between the level C3 at first and fourth day. Any correlation between CRP and C3 in patients with ACS. PATIENT AND METHODS: 129 subjects (94 male and 35 female) age range (41-72 years, mean age 57 ± 10.6) were admitted in this study over the period of Feb 2009-Jan 2010 categorized into three groups; 76 patients with acute coronary syndrome (group A), 25 patients with stable angina (group B) and 28 healthy control (group C). Full clinical, biochemical, electrocardiographic and echocardiographic studies liveredone. All patients were followed to the fourth day of admission, Blood samples from peripheral veins were collected centrifuged and Serum C3 levels were measured using immunokit based on single immunodiffusion. RESULTS: The sample of patients was (129) subjects (94 male 72.9%) and (35 female 27.1%). Troponin (I) was positive in 35.7% and negative in 64.3% of the study sample (p. value 0.0005). C-reactive protein (CRP) was significantly correlated with different groups (p. value 0.0004).the same with diabetes mellitus (p. value 0.0003) but not in hypertensive and smokers (p. value 0.486 and 0. 368 respectively).C3levels was significant in correlation to clinical status in both STEMI and NSYEMI 1st and 4th day. Correlation between C3 and C-reactive protein level was insignificant with different groups. CONCLUSION: C3 levels was significantly elevated in correlation between ACS compared to patient with stable angina and healthy control subjects. Also C3 level was significant at the fourth day of admission in patients with NSTEMI in correlation to its level at the first day. However no significance associations between C3 levels and CRP in different studied groups