Abstract

ABSTRACT:
BACKGROUND:
Alpha1-adrenoceptor blocking agents showed several effects beyond their action on the vascular smooth muscles. They improve the lipid profile and inhibit the aggregation of blood platelets.
OBJECTIVE:
To investigate the clot-lysis effect of selective α1-adrenoceptor antagonists and its relation to peroxynitrite level in vitro experimental model.
MATERIALS AND METHODS:
Venous blood samples obtained from ten healthy subjects. To each pre-weighed clot, 100 μL of either distilled water as a negative control, prazosin (10 μg), terazosin (20 μg) and alfuzosin (25 μg) were added. Peroxynitrite level was measured in sera and sangious fluid that formed after clot-lysis.
RESULTS:
Prazosin, terazosin and alfuzosin,in order, significantly reduced the clot weight up to 3.7%. Peroxynitrite level in sangious fluids was higher in treated groups than that of negative control or sera levels.
CONCLUSION:
α1-adrenoceptor antagonists induced clot-lysis effect. This effect is associated with generation peroxynitrite