Abstract

ABSTRACT :
BACKGROUND:
Fat cells, are the cells that primarily compose adipose tissue, specialized in storing energy as fat. Adipose tissue also serves as an important endocrine organ by producing hormones such as leptin, resistin, and the cytokine. Leptin is a protein hormone that plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism. Acute Myocardial Infarction (AMI), is the interruption of blood supply to part of the heart, causing some heart cells to die.
OBJECTIVE:
To investigate the levels of leptin and its effect on lipid profile level in Acute Myocardial Infarction.
SUBJECTS AND METHODS:
The study included 50 patients with Acute Myocardial Infarction and forty healthy subject as control group. leptin and lipid profile levels were measured.
RESULTS:
The levels of leptin were significantly elevated in female patients group with(p=0.002), in male patients group(p=0.018) and in total patients group (p=0.001), cholesterol and LDL-C were significantly elevated with (p<0.001), while HDL-C was significantly lower with (p<0.001), there was positive correlation between leptin with , cholesterol LDL-C, triglyceride and VLDL, and there was negative correlation between leptin with HDL in acute myocardial infarction patients.
CONCLUSION:
Leptin negatively correlated with HDL and positively correlated with triglyceride and LDL this relation make this hormone act as atherosclerotic factor.