ABSTRACT: BACKGROUND: Fibromyalgia syndrome (FMS) is a common rheumatologic syndrome with multiple systemic manifestations & associated with many diseases. OBJECTIVE: To assess fibromyalgia syndrome in inflammatory bowel disease. PATIENTS AND METHODS: One hundred four Iraqi patients with inflammatory bowel disease were studied and compared with another (112) healthy individuals matched for age and sex as a control group. Full history was taken and complete clinical examination was done for all individuals in both groups. Fibromyalgia syndrome was diagnosed in all patients on base of the American College of Rheumatology (ACR) 1990 Criteria for the classification of FMS. Inflammatory bowel disease was detected by colonoscopy & tissue biopsy. RESULTS: There was a significant increase in the frequency of FMS among individuals with IBD (24 %) compared to healthy control group (5.4%) ((P-value =0.0001, Odd ratio=0.18, 95% CI=0.07-0.46). CONCLUSION: FMS occurs with increased frequency in IBD.