Abstract

ABSTRACT:
BACKGROUND:
Acute leukemia is a clonal hematopoietic malignant disease that arises from malignant transformation of an early hematopoietic stem cells .Seeking for biochemical markers that are associated with acute leukemia may help us for better understanding of the leukemic process &improve our lines of management.Hypolipoproteinemia is one of these markers&it is the target of this study.
OBJECTIVE:
To study the association between the hypolipoproteinemia ´ leukemia &the ability of using hypolipoproteinemia as a biological marker that is helpful in follow up of acute leukemia.
PATIENT&METHODS:
A total of fifty patients with acute leukemia diagnosed by blood film&bone marrow examination were compared with control group of twenty healthy persons regarding fasting lipid profile(TC total cholesterol,LDL low density lipoprotein,HDL high density lipoprotein,TG triglyceride).
RESULTS:
In this study there is close association between hypolipoproteinemia´ leukemia. The mean values of lipoproteins were significantly lower in patient with acute leukemia compared to control group(P value is 0.0001 for total cholesterol&0.045 for triglyceride).
CONCLUSION:
These data suggest that hypolipoproteinemia could be useful as a marker for follow up of acute leukemia.