Abstract

ABSTRACT:
BACKGROUND:
Epileptic patients exhibited variably altered status of electrolytes, and antioxidant.
OBJECTIVE:
The aim of this study is to investigate the effect of epilepsy and long-term antiepileptic drug therapy on the level of serum electrolytes (calcium, sodium, and potassium) and antioxidant ( uric acid) .
PATIENTS AND METHODS:
Thirty epileptic patients and twenty normal healthy individuals as a control were recruited in this study. The mean± SD of age of treated and untreated patients was (24.0±10.0) and (31.0±11.0) respectively.
Spectrophotometric technique was used to determine all the parameters in this study.
Data were expressed as mean ± SD. Statistical comparison among different groups was performed by using ANOVA tests. Statistical significance was defined. as P<0.05.
RESULTS:
The treated group (particularly with valproate), show increases in the levels of calcium, sodium, with no difference in potassium. however among untreated epileptics, uric acid level was increased.
CONCLUSION:
The above parameters differs in epileptics comparable to controls and hence their correlation to seizures pathophysiology and their degree of control or resistance to antiepileptic drug therapy