Abstract

ABSTRACT: BACK GROUND:
Ischemic heart diseases (I.H.D) become more common during 21st century as the dominant chronic diseases in many parts of the world, and it is predicted to be become the main causes of disability and death world wide. Many factors play a role in pathogenesis of I.H.D among those could be immuno-inflammatory markers which may lead to development of this disease.
OBJECTIVE:
The present study was conducted to obtain more clarification about the impact of some immuno-inflammatory markers (IL-6, CRPand ESR value) on the clinical expression of heart disease among Iraqi patients.
METHODS:
Hundred Iraqi patients with I.H.D (80 male and 20 female) ages ranged from 20 to 80 year were involved in this study, including 4 subgroups: 17 with heart failure (H.F). ; 26 with myocardial infraction (M.I); 12 with stable angina (S.A) and 45 with unstable angina (U.A) who was attending the Iraqi center for heart disease and Baghdad hospital from December 2006 to march 2007. Using enzyme amplified sensitivity immuno assay (EASIA) technique to measure the level of IL-6, and enzyme linked immunosorbant assay (ELISA) technique to measure the levels of CRP, in addition to westergren method to determine ESR were done for both patients groups and healthy control group.
RESULTS:
Significant increased (p<0.05) in the serum level of IL-6 in all patients subgroups: MI, HF, UA, and SA. Respectively compared with control group, also all patients subgroups: SA, HF, MI, UA, consequently revealed significant increased (p<0.05) in the mean of CRP concentration compared with control group. Moreover, highly significant elevated (p<0.01) in the erythrocyte sedimentation rate (ESR) value in the patients subgroups: SA, UA, MI, HF respectively compared with control group.
CONCLUSION:
Elevated levels of inflammatory markers, particularly CRP and IL-6 are a relatively strongly predictor of I.H.D and in one way or another ESR value and CRP level reflect the degree of the inflammatory status of these diseases.