Abstract

ABSTRACT:
BACKGROUND :
p53 gene is the most common mutation in human cancers.In bladder cancer, p53 mutations have been
associated with high tumor grades and advanced stages.Moreover,p53 nuclear over expression
appears to be an independent predictor of disease progression and decreased survival after
cystectomy.
OBJECTIVE:
To identify the role of p53 nuclear protein in prediction the progression and recurrence of superficial
tumor of the bladder in response to intravesical chemotherapy
PATIENTS AND METHOD :
The expression of p53 protien was studied by immunohistochemical analysis from 71 patients with
superficial tumor bladder and all of them were treated by intravesical chemotherapy followed
periodically every three months by cystoscopy
RESULT :
P53 over expression was observed in 38out of 71(54%) patients with superficial tumor of the bladder.
A statisticaly significant relation was noticed between P53 over expression and tumor grades ,
however statistical significant relation between p53 negative expression and response to intravesical
mitomycin C chemotherapy was noticed , moreover , patients who received intravesical mitomycin
C chemotherapy , 71% showed response with in 3 month , while 29% showed recurrence .
Moreover, it seems that P53 status did predict response to intravesical mitomycin C chemotherapy.
CONCLUSION :
The response of intravesical chemotherapy in patients with superficial transitional cell carcinoma was
higher in p53 negative expression.