Abstract

ABSTRACT: BACK GROUND: Monocrotophos (MCP) is an organophosphorus insecticide has both systemic and contact actions and has been used against insects. METHODS: Thirty six male Balb/c mice were used. These were divided into six group (A, B, A1, B1, A2, B2, ). MCP was given orally daily by gavage 1/5th of LD50 (0.28 mg/100gm of body wt.), vitamin E and vitamin C was given orally daily by gavage @ 100 mg /kg body wt., while MCP+ Vitamine E and MCP + Vitamine C was also given. RESULTS: The signs of MCP toxicity include shivering, salviation and Iacrimation. Scanining electron microscopy (SEM) revealed that of erythrocytes in control were perfect discocytes (D). MCP treatment resulted in drastic alteration in the topography of erythrocytes. Vitamin E and Vitamin C treated mice revealed normal erythrocyte like that in control. MCP+ Vitamin E and MCP + vitamin C treated mice revealed almost normal of topography of erythrocyte. CONCLUSION: Pesticide exposure could be prevented by CO- administration antioxidant Vitamin E or Vitamin C.