Diabetes mellitus is a heterogeneous condition reflecting different metabolic disorders accompanied by a variety of complications. In DM, there is a change in oxidative stress (elevation in free radical generation with increase lipid peroxidation and derived oxidized products, and serum lipid profile abnormalities.
Several free radical species are normally produced in the body to perform specific functions. Increased free radicals in diabetes may cause the pathogenesis of atherosclerosis, and the degenerative disorders. In the present study, the oxidative stress in type 2 diabetic male patients was evaluated by estimating the lipid peroxidation. Malondialdehyde (MDA) is one of the major aldehyde derived from lipid peroxidation.
PATIENTS AND METHODS:
Serum MDA, Oxidized HDL (ox.HDL), and lipid profile were measured after 12 hr fasting in 30 diabetic patients, their age range was (40-55) years and compared with 30 healthy controls. RESULTS:
Serum MDA and ox.HDL were significantly increased in the diabetic group (P<0.05). All patients had significant elevation in serum levels of glycated hemoglobin (HbA1c), total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), and LDL particles size index (TG/HDL-C ratio).
This may be due to different glycemic control in these patients. There was a significant positive correlation between serum MDA and LDLs size index, while serum MDA was negatively correlated with serum HDL-C in diabetic patients. Our results indicate that oxidative stress status increases during type 2 diabetes mellitus in parallel to glucose and lipid changes