Abstract

ABSTRACT:
BACKGROUND :
Acute myocardial infarction ( AMI ) is an important clinical condition which is associated with a significant inflammatory changes that result in acute-phase responses. Significantly elevated concentrations of cytokines and other acute phase reactants are the major events that accompanied such condition. Our aim was to evaluate certain acute phase reactants : Interleukin-6 ( IL-6 ) , C-Reactive Protein ( CRP ) and plasma fibrinogen in patients with AMI.
OBJECTIVE:
This study was focused on the evaluation of certain acute phase reactants : Interleukin-6 ( IL-6 ) , C-Reactive Protein ( CRP ) and plasma fibrinogen in patients with AMI.
PATIENTS AND METHODS:
Thirty patients from Baghdad city with AMI were included between July 2011 and January 2012 : 21 males and 9 females, their ages range between 40 – 73 years. Thirty healthy subjects ( 16 males, 14 females ), age matched with patients as a comparative group were included. Both groups were investigated for IL-6 , CRP , and plasma fibrinogen levels.
RESULTS :
IL-6 concentrations were found to be significantly higher with ( P value : 0.0001 ) –table 1- in patients with AMI) than in control subjects. CRP concentrations were also found to be significantly higher with ( P value : 0.0001 ) in patients with AMI than in control subjects. plasma fibrinogen level was significantly higher with ( P value : 0.0001 ) in patients with AMI than in control subjects.
CONCLUSION :
The study revealed a significant elevation in IL-6 , CRP concentrations and plasma fibrinogen level in patients with AMI.